Structures of fucose-containing ceramide pentasaccharides from the plasma of blood group O Le(a−b−) nonsecretors
- 20 August 1984
- journal article
- Published by Wiley in FEBS Letters
- Vol. 174 (1), 55-60
- https://doi.org/10.1016/0014-5793(84)81077-7
Abstract
A minor, Lec blood‐group inactive ceramide pentasaccharide double band fraction has been isolated from the plasma of blood group O Le(a−b−) nonsecretors. The two purified glycolipids were analysed by NMR spectroscopy, mass spectrometry and combined gas chromatography‐mass spectrometry. The following structures could be established: GlcNAc(β1 → 3)Gal(β1 → 4)Glc(β1 → 1)Cer (I); Gal(β1 → 4) [Fuc(α1 → 3)]GlcNAc(β1 → 3)Gal(β1 → 4)Glc(β1 → 1)Cer (II). It must be concluded that at least part of the secretor gene‐independent plasmatic H type 2 blood‐group activity can be attributed to glyco‐sphingolipid I, whereas substance II, originally detected in cancerous tissue, also occurs in the plasma of healthy individuals.Keywords
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