METABOLISM OF THE ESTROGENS THE EFFECT OF LIVER AND UTERUS UPON ESTRONE, ESTRADIOL AND ESTRIOL1,2,3

Abstract

In vitro studies indicate that estrone is strongly reduced to estradiol by uterine tissue, less actively by other organs. Liver inactivates estrone, probably by enzymatic oxidation; this inactivation is inhibited by NaCN. Estriol is only mildly affected by liver and is not increased in potency by the action of uterine or other tissues; this indicates that the metabolic fate of estriol is different from that of estrone and estradiol.