Quality control in the endoplasmic reticulum protein factory
Top Cited Papers
- 1 December 2003
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 426 (6968), 891-894
- https://doi.org/10.1038/nature02262
Abstract
The endoplasmic reticulum (ER) is a factory where secretory proteins are manufactured, and where stringent quality-control systems ensure that only correctly folded proteins are sent to their final destinations. The changing needs of the ER factory are monitored by integrated signalling pathways that constantly adjust the levels of folding assistants. ER chaperones and signalling molecules are emerging as drug targets in amyloidoses and other protein-conformational diseases.Keywords
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