Leukopenia and Anemia in the Monkey Resulting from Vitamin Deficiency

Abstract

Young monkeys (Macaca mulatta) were given a diet believed to be adequate with respect to protein, inorganic elements, fatty acid, vitamins A, B(B₁), C, and D, but deficient in vitamin G(B₂) and possibly deficient in other less well-known organic substances which may be essential to the nutrition of the monkey. After a varying period on the diet, the animals developed a fulminating, fatal blood disease, characterized by anemia and leukopenia. Ulceration of the gums was a consistent accompaniment of the hypocythemia, and diarrhea was common. There was a progressive decrease in blood cholesterol, but no significant change in the blood sugar level. Blood urea remained normal until the last 2 days of life, at which time the level of this substance became somewhat elevated. There was no retention of creatinine. The deficient diet supplemented with dried brewers' yeast supported good growth and prevented the deficiency syndrome.