Metabolism of C14 Histamine in Man
- 1 November 1956
- journal article
- research article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 9 (3), 481-483
- https://doi.org/10.1152/jappl.1956.9.3.481
Abstract
Three normal men were injected intradermally with microgram quantities of C14 histamine. Most of the C14 appeared in the urine within 6 hours. Analysis of this urine showed that 1-methylimidazole-4-acetic acid is the principal metabolite, with smaller quantities of 1-ribosylimidazole-4-acetic acid, imidazoleacetic acid, 1-methyl-4-(β-aminoethyl) imidazole, and unchanged histamine also present. A discussion of the quantitative aspects of the assays is given. Note: with the technical assistance of Rosa L. Smiley and K. Jane Davis. Submitted on June 27, 1956Keywords
This publication has 2 references indexed in Scilit:
- RING N METHYLATION; A MAJOR ROUTE OF HISTAMINE METABOLISMJournal of Biological Chemistry, 1956
- URINARY METABOLITES OF RADIOACTIVE HISTAMINEJournal of Biological Chemistry, 1956