SEROLOGIC INVESTIGATIONS OF MYCOBACTERIAL ANTIGENS .5. INFLUENCE OF NORMAL SERUM COMPONENTS ON THE SENSITIZATION AND REACTIVITY OF ANTIGEN-TREATED SHEEP ERYTHROCYTES
- 1 January 1957
- journal article
- research article
- Published by Elsevier
- Vol. 75 (6), 958-964
- https://doi.org/10.1164/artpd.1957.75.6.958
Abstract
BCG extract antigens were eluted from sheep erythrocytes by normal serum. The eluting factor was associated with the albumin fraction. OT-sensitized sheep cells were unaffected. Interaction between BCG extract-treated erythrocytes and homologous antibody prevented elution of the complex from the erythrocyte upon subsequent exposure to normal serum. Sensitization of sheep erythrocytes by OT and BCG extract antigens failed in the presence of normal human or rabbit serum or albumin in dilutions of 1:128.Keywords
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