EVIDENCE THAT THE SEGREGATION-DISTORTION PHENOMENON IN DROSOPHILA INVOLVES CHROMOSOME BREAKAGE
- 1 August 1962
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 48 (8), 1307-1314
- https://doi.org/10.1073/pnas.48.8.1307
Abstract
Sandier, Hiraizumi, and Sandier suggested that the distorted segregation ratios in the Segregation-distorter (SD) strains of Drosophila occurred because the SD chromosome produced something analogous to a break in the normal homolog leading somehow to nondeveloping or nonfunctional gametes. The present experiment was designed to determine whether an actual break is induced, by finding recombination between such a break and one induced by radiation. When distorting males were X-rayed they produced a significantly larger fraction of chromosomes showing recombination in or near the SD region than irradiated control males where distortion was not occurring. Thus the SD effect on the homolog appears to be an actual chromosome break by the criterion of being able to rejoin with a radiation-induced break.Keywords
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