A Multisubunit Ribozyme That Is a Catalyst of and Template for Complementary Strand RNA synthesis
- 29 March 1991
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 251 (5001), 1605-1608
- https://doi.org/10.1126/science.1707185
Abstract
Derivatives of the sunY self-splicing intron efficiently catalyzed the synthesis of complementary strand RNA by template-directed assembly of oligonucleotides. These ribozymes were separated into three short RNA fragments that formed active catalytic complexes. One of the multisubunit sunY derivatives catalyzed the synthesis of a strand of RNA complementary to one of its own subunits. These results suggest that prebiotically synthesized oligonucleotides might have been able to assemble into a complex capable of self-replication.Keywords
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