Although Gaucher's splenomegaly is a disease with striking clinical characteristics almost as unique and unmistakable as the appearance of the big cells that cause the enlargement of the spleen, the diagnosis has very rarely been made except by microscopic examination. Apparently, this has been so because the comparatively few cases reported and the absence from the literature of any pictures illustrating the skin and eye signs have made this disease relatively unfamiliar to clinicians, although it is well known to pathologists. The only form of treatment which has found general favor has been splenectomy. Apparently this has been done because the spleen was obviously the chief organ affected and at least some relief from symptoms caused by its bulk might be expected from its removal. For many years it has been known that the liver, bone marrow and lymph glands also contain the same large, mysterious cells that are found