Respiratory Distress Syndrome and Thrombotic, Non‐Bacterial Endocarditis after Amitriptyline Overdose
- 12 January 1977
- journal article
- research article
- Published by Wiley in Acta Medica Scandinavica
- Vol. 202 (1-6), 203-212
- https://doi.org/10.1111/j.0954-6820.1977.tb16813.x
Abstract
Patients [3] with documented or suspected amitriptyline [a trycyclic antidepressant] poisoning developed a uniform clinical picture with progressive respiratory insufficiency, thrombocytopenia and evidence of embolization. Post-mortem examination revealed equally uniform changes: thrombotic, non-bacterial endocarditis (TNBE) with multiple embolization and marked pulmonary stiffness with extensive invasion of alveoli with connective tissue. The lung pathology and clinical picture of progressive respiratory insufficiency agree with respiratory distress syndrome (RDS) in the adult. Simultaneous occurrence of RDS and TNBE suggests a similar pathogenesis. Prophylactic measures are described.This publication has 26 references indexed in Scilit:
- Fine structural alterations in the lungs of iprindole‐treated ratsThe Journal of Pathology, 1974
- PROGRESSIVE PULMONARY CONSOLIDATIONPublished by Wolters Kluwer Health ,1972
- The microembolism syndromeForensic Science, 1972
- The Use of Diuretics in the Treatment of Early Wet Lung SyndromeAnnals of Surgery, 1972
- The effect of imipramine-like drugs and antihistamine drugs on uptake mechanisms in the central noradrenaline and 5-hydroxytryptamine neuronsNeuropharmacology, 1971
- Effect of Prednisolone on the Coagulation and Fibrinolytic SystemsScandinavian Journal of Haematology, 1970
- Nonbacterial thrombotic endocarditis. Clinical recognitionArchives of Internal Medicine, 1970
- OXYGEN TOXICITY AS A FACTORPublished by Wolters Kluwer Health ,1968
- Blood and Tissue Changes in the Dog during and after Excessive Free Fatty Acid MobilizationActa Medica Scandinavica, 1965
- Inhibition of noradrenaline uptake by drugsJournal of Pharmacy and Pharmacology, 1965