Local Immunity in Mumps Meningitis
- 1 November 1980
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Pediatrics & Adolescent Medicine
- Vol. 134 (11), 1060-1064
- https://doi.org/10.1001/archpedi.1980.02130230040012
Abstract
• Titers of antibodies to mumps and measles virus and interferon activity were measured in sera and CSF obtained from 15 children with mumps meningitis. Antibody to mumps virus was found in 11 of 15 CSF samples. Evaluation of the CSF-serum ratio for antibodies to both viruses showed a substantially higher ratio for antibody to mumps virus. The ratio of IgG/IgM antibody activity to mumps virus was greater in CSF than in sera. These results could be attributed to antibody synthesis, particularly IgG, in the CNS. Titers of antibodies to mumps virus in CSF increased rapidly, reaching a peak four to ten days from onset of meningitis, and swiftly decreased thereafter. During the acute phase, interferon activity was found in almost all cases ranging from 16 to 128 IU/mL in sera, and 4 to 16 IU/mL in CSF. In cases of mumps meningitis that followed the usual clinical course, interferon disappeared within a week, whereas it persisted in the CSF in cases of persistent pleocytosis. (Am J Dis Child 134:1060-1064, 1980)This publication has 15 references indexed in Scilit:
- Demonstration of cerebrospinal fluid lymphocytes sensitized against virus antigens in mumps meningitisActa Neurologica Scandinavica, 1978
- The Central Nervous System-Associated Immune Response to Parainfluenza Type I Virus in MiceThe Journal of Immunology, 1978
- Central Nervous System Immunity in Mice Infected with Theiler's Virus. I. Local Neutralizing Antibody ResponseThe Journal of Infectious Diseases, 1978
- Adenine Arabinoside Therapy of Biopsy-Proved Herpes Simplex EncephalitisNew England Journal of Medicine, 1977
- MEASLES MORTALITY: A RETROSPECTIVE LOOK AT THE VACCINE ERA1American Journal of Epidemiology, 1975
- Appearance of Cytotoxic T Cells in Cerebrospinal Fluid of Mice with Ectromelia Virus-Induced MeningitisScandinavian Journal of Immunology, 1974
- Production of High-Titered Interferon in Cultures of Human Diploid CellsAntimicrobial Agents and Chemotherapy, 1972
- Recovery of an Interferon-Like Substance from Cerebrospinal Fluid.Experimental Biology and Medicine, 1964
- Hemagglutination and hemagglutination-inhibition with measles virusVirology, 1961
- Continuous Cultivation of Epithelial Cell Strain (FL) from Human Amniotic Membrane.Experimental Biology and Medicine, 1957