Effect of Induced Elevated Plasma Levels of Homocystine and Methionine in Rats on Collagen and Elastin Structures
- 1 January 1976
- journal article
- research article
- Published by Taylor & Francis in Connective Tissue Research
- Vol. 4 (2), 101-106
- https://doi.org/10.3109/03008207609152205
Abstract
Young growing rats were intraperitoneally injected with mixtures of homocystine and methionine for several weeks. The growth of the animals was inhibited. After 3 weeks 25% of the rats died and isolation of tail tendon collagen and aorta elastin showed that these proteins were deficient in chemical cross-links. Seventy-five % of the rats survived further injections for another 3 weeks and isolated collagen and elastin were found to be normal in cross-linking. The variability in susceptibility of these rats to homocystine-methionine treatment is discussed in relationship to human homocystinuria. It is speculated that the variability is due to variability in in vivo homocysteine levels.Keywords
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