The Relationship Between Alkaline Phosphatase in the Kidney and Urinary Calculi

Abstract

Rabbits maintained on oxamide with and without ureteral obstruction developed urinary calculi. In kidneys with hydronephrosis or atrophy, there was an almost complete loss of alkaline phosphatase. Calculi developed in one of these kidneys. No definite connection between the amount of alkaline phosphatase present and the formation of renal calculi was observed in either rabbits or rats. However, there seemed to be a decrease in alkaline phosphatase in those kidneys where calculi developed. Albino rats maintained on a vit. A deficient diet developed urinary calculi in about 70% of the cases.