The Influence of Coprophagy on the Biotin and Folic Acid Requirements of the Rat

Abstract
Rats fed purified diets and kept in coprophagypreventing tube cages grew significantly better when folic acid and biotin were added to the diet than when these vitamins were omitted. Inositol, p-aminobenzoic acid, and niacin did not affect the growth rate of these rats. Biotin and folic acid produced only slight and irregular improvement in the growth of rats kept in ordinary screen-bottom cages. The separate effects of coprophagy-prevention and the addition of sulfasuxidine were reflected also in the biotin and folic acid content of the liver, but not in the nicotinic acid content.