THE EFFECT OF DIETARY FAT ON THE UTERINE WEIGHT RESPONSE OF IMMATURE MICE TO ORAL STILBESTROL

Abstract

The effect of dietary fat on the uterine weight of the immature mouse and the uterine weight response to stilbestrol added to the diet has been studied. Increasing the fat content of either beef or chicken lean tissue diets results in greater growth of the mouse as measured by an increase in body weight, and also in an increase in the uterine weight. The increase in uterine weight is proportionally greater than the increase in body weight. On the other hand, the uterine weight response to added stilbestrol in the diet of the mouse is decreased as the fat content is increased. The significance of these findings in the interpretation of estrogenic assay based on the mouse uterine weight method is discussed.[long dash]Auth. abst.