Hla antigens and rheumatoid arthritis association between hla‐drw4 positivity and igm rheumatoid factor production
Open Access
- 1 March 1980
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 23 (3), 309-313
- https://doi.org/10.1002/art.1780230307
Abstract
Serologic HLA typing was carried out on 33 seropositive and 15 seronegative patients with rheumatoid arthritis (RA). Association with the DRw4 antigen was found only in seropositive RA (61%, compared with 27% in normal controls; P < 0.05, Fisher's exact test), whereas the antigen had a normal frequency in seronegative RA patients (27%). The serum concentrations of IgM and IgE immunoglobulins were significantly higher in seropositive than in seronegative RA patients (P < 0.01, Mann-Whitney test), whereas the concentrations of the other immunoglobulin classes and of the complement factors C3 and C4 did not show any significant differences.This publication has 13 references indexed in Scilit:
- HLA-DRw4 AND RHEUMATOID ARTHRITISThe Lancet, 1979
- Evidence of Similar Idiotypic Determinants on Different Rheumatoid Factor PopulationsScandinavian Journal of Immunology, 1979
- HLA—Dw4 and Rheumatoid ArthritisTissue Antigens, 1979
- Serological typing of HLA-D: Predictive value in mixed lymphocyte cultures (MLC)Immunogenetics, 1978
- Association of the B-Cell Alloantigen DRw4 with Rheumatoid ArthritisNew England Journal of Medicine, 1978
- Certain Rheumatoid Factors React with both IgG and an Antigen Associated with Cell NucleiScandinavian Journal of Immunology, 1978
- The HLA-D determinantsImmunogenetics, 1977
- Increased Frequency of HLA‐Cw3 and HLA‐Dw4 in Rheumatoid ArthritisArthritis & Rheumatism, 1977
- Rheumatoid factor: Its nature, specificity, and production in rheumatoid arthritisClinical Immunology and Immunopathology, 1976
- The Reaction of Rheumatoid Anti‐Gm Antibodies with Native and Aggregated Gm‐Negative IgGScandinavian Journal of Immunology, 1974