cDNA cloning and regional distribution of a novel member of the opioid receptor family
- 18 April 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 343 (1), 42-46
- https://doi.org/10.1016/0014-5793(94)80603-9
Abstract
We have cloned a cDNA for a novel member of the opioid receptor family, designated as ROR-C, from the rat cerebrum cDNA library using the probe derived from the δ-opioid receptor subtype cDNA. The deduced amino acid sequence of ROR-C shows high homology with those of ROR-A (rat δ-opioid receptor subtype), ROR-B (rat μ-subtype) and ROR-D (rat k-subtype). RNA blot hybridization and in situ hybridization analysis revealed that ROR-C mRNA is expressed in discrete regions of the rat central nervous system.Keywords
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