Thrombocytopenia Occurring During Chlorpropamide Therapy

Abstract

After 15 days of treatment with 250 mg daily of chlorpropamide, a diabetic patient developed diffuse petechiae and hemorrhagic skin manifestations associated with the complete disappearance of platelets from the peripheral smear. Withdrawal of chlorpropamide and the use of steroid therapy resulted in a prompt remission. It is very likely that chlorpropamide caused the thrombocytopenia.