MIXED CONGLUTINATION REACTION

Abstract

The technique of mixed conglutination[long dash]a mixed aggregation technique for the detection of complement fixing antibodies to antigens on cell surfaces[long dash]is described. The immune systems to which this technique has been applied include: (a) The detection of H-2 antibodies in the mouse. (b) The detection of organ specific iso-antibodies in the mouse. (c) The detection of Forssman antigen on a continuous tissue culture line of dog cells using an immune anti-Forssman serum. (d) The detec-tion of an auto-antibody-like factor occurring in normal guinea-pigs reacting with their own testicular tissue.