The goal of long-term survival or cure of the patient with infiltrating bladder cancer continues to be a seemingly insurmountable challenge for the urologist. The last two decades have witnessed continued efforts not only in the form of earlier1and more radical2surgical approaches, made possible by well recognized advances in operative technique with associated supportive measures and by improved methods of urinary diversion, but also in the form of improvement in techniques and facilities of radiation therapy, particularly the increasing use of high-energy external teletherapy equipment such as radioactive cobalt, linear accelerators, and betatrons. We look hopefully to the discovery of a biologically specific chemical agent to further augment the therapeutic modalities available to the patient and his physician. It is impossible and obviously unwise to attempt to make routine the treatment program for patients with infiltrating bladder cancer. The many variaables include the site, extent, and