An Interferon-Like Viral Inhibitor in Body Fluids of Endotoxin-Injected Rabbits.

Abstract

Summary An interferon-like viral inhibitor in serum, ocular aqueous humor, urine and cerebrospinal fluid (CSF) of rabbits was titrated in primary rabbit kidney cell cultures with vesicular stomatitis virus (VSV) after intravenous injection of 200 μg of typhoid endo toxin. The inhibitor was detected in the serum, urine and CSF as early as 1 hour and in the aqueous humor at 2 hours after the en-do toxin injection. No inhibitory activity was demonstrated in any specimen obtained after 8 hours. The highest peak titer of inhibitor was detected in the serum and the lowest in the CSF. The experimental data indicate the passage of the viral inhibitor from the blood into the aqueous humor, urine and CSF of rabbits following intravenous injection of typhoid endo toxin.