Replication of human adenoviruses in guinea pig embryo cells: an ultrastructural study
- 1 December 1987
- journal article
- research article
- Published by Springer Nature in Archiv für die gesamte Virusforschung
- Vol. 93 (3-4), 247-260
- https://doi.org/10.1007/bf01310978
Abstract
Guinea pig embryo (GPE) cells showed different degrees of susceptibility to human adenovirus types as determined by virus infectivity assay and electron microscopic examination. Adenovirus 2 and 5 induced extensive cellular changes and produced high titers of infectious virus in GPE cells as in human cells. Mature progeny virus and protein crystals were observed in both cell types. Adenovirus 7 induced some cellular changes in GPE cells but only a small number of cells yielded progeny virus as determined by electron microscopy. Adenovirus 3, 8 and 31 induced some cellular changes but no progeny virus was found under electron microscopic examination. Characteristic fibers were observed in nuclei of adenovirus 31 infected cells. The ability of human adenovirus 2 and 5 to replicate in GPE cells is an example of an unusual cross-species biological property of certain adenovirus types. This property may be useful as a biological marker for these virus types.This publication has 25 references indexed in Scilit:
- Ultrastructural Development of Guinea Pig Cytomegalovirus in Cultured Guinea Pig Embryo CellsJournal of General Virology, 1979
- Further Subgrouping of the Human Adenoviruses by Differential HemagglutinationThe Journal of Infectious Diseases, 1973
- The response of BHK21 cells to infection with type 12 adenovirusArchiv für die gesamte Virusforschung, 1970
- Nonproductive infection of baby hamster kidney cells (BHK21) with adenovirus type 12Virology, 1969
- Cytopathogenicity and replication of human adenovirus type 6 in cultured bovine cellsCanadian Journal of Microbiology, 1969
- Electron microscopic observations on multiple polyoma virus-related particlesVirology, 1967
- A GENERAL REVIEW OF THE ADENOVIKUSESAnnals of the New York Academy of Sciences, 1962
- OBSERVATIONS ON THE FINE STRUCTURE OF POLYOMA VIRUSThe Journal of cell biology, 1960
- A CORRELATIVE STUDY BY ELECTRON AND LIGHT MICROSCOPY OF THE DEVELOPMENT OF TYPE 5 ADENOVIRUSThe Journal of Experimental Medicine, 1960
- An Electron Microscope Study of Polyoma Virus in Hamster KidneyThe Journal of cell biology, 1960