Acidosis is now generally known to be present in various diseases, such as diabetes, nephritis, uremia, and when violent diarrhea and vomiting occur clinically, there is also a rapid decrease in the body fluids. In most cases of cholera, the victim falls into a state of temporary inanition, and in consequence of the action of the toxin on the kidneys, so-called cholera nephritis very often develops. The decrease of blood alkali and the accumulation of acid in the body, make the existence of acidosis a certainty. Sellards noted the remarkable tolerance of the urine to alkali, while Rogers observed a notable decrease of alkali in the blood. During the cholera epidemic of last year, 529 cases were treated in the Dairen Isolation Hospital. Owing to a lack of apparatus Van Slyke's method for the determination of acidosis could not be employed. Traube's quinin method was resorted to instead, and the