Defective association of dystrophin with sarcolemmal glycoproteins in the cardiomyopathic hamster heart
- 23 August 1993
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 329 (1-2), 227-231
- https://doi.org/10.1016/0014-5793(93)80227-l
Abstract
In ventricular muscle from 30- to 60-day-old Bio 14.6 cardiomyopathic hamsters, dystrophin-associated glycoproteins of 43, 50 and 150 kDa are markedly reduced in abundance. In particular, the 50-kDa glycoprotein is totally deficient in the sarcolemma of myopathic ventricular myocytes as revealed by immunofluorescence microscopy. The dystrophin-glycoprotein complex formation is defective in the cardiomyopathic hamster heart, because dystrophin and the glycoproteins behave independently when digitonin-solubilized ventricular homogenates are fractionated on wheat germ agglutinin beads or anti-dystrophin immunoaffinity beads.Keywords
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