Processing of tRNA Is Accomplished by a High-Molecular-Weight Enzyme Complex

Abstract

A complex of functionally related enzymes is in essence a highly concentrated manufacturing unit completing various steps simultaneously or sequentially on the same or related substrates. The substrates are efficiently available to all enzymes. Enzymes of the complex could influence each other’s activities through their physical association or their prior action on the substrate. Such influence affects regulation of metabolic processes. Regulation, or the lack of it, is of primary interest to the elucidation of molecular oncology.