THE PRODUCTION OF GAMMA-GLOBULIN IN THE CENTRAL NERVOUS SYSTEM
Open Access
- 1 August 1954
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 17 (3), 228-232
- https://doi.org/10.1136/jnnp.17.3.228
Abstract
Electrophoretic studies of the cerebrospinal fluid and serum proteins were made on 26 cases of disseminated sclerosis, 3 of multiple myeloma, 2 of neurosyphillis and 4 normal controls. In chronic inflammatory disease the gamma-globulin/albumin ratio of the cerebrospinal fluid exceeded that of the serum and was more variable than the alpha plus beta globulin/albumin ratio, indicating gamma-globulin production in the central nervous system. A raised lymphocyte count accompanied the rise in gamma-globulin.Keywords
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