MODIFICATION OF ABNORMAL SERUM LIPID PATTERNS IN ATHEROSCLEROSIS BY ADMINISTRATION OF SITOSTEROL
- 1 October 1956
- journal article
- research article
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 45 (4), 614-622
- https://doi.org/10.7326/0003-4819-45-4-614
Abstract
In experimental animals fed a high cholesterol diet the plant sterol, beta-sitosterol, interfered with absorption of cholesterol and prevented its accumulation in serum and liver. Prolonged administration to man of sitosterol in the daily dosage of 18 to 25 g resulted in sustained reduction in serum cholesterol. In the 24 patients treated, the mean decrease in serum cholesterol was 15.5% of the control level. Patients with myxedema were most responsive to sitosterol adminstration.Keywords
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