Entropy–enthalpy compensation and anticompensation: solvation and ligand binding

Abstract

Plots of ΔH° versusTΔS° are misleading and can suggest an apparent linear relationship (compensation) with a slope near to unity when ΔS° has been obtained from experimental ΔG° and ΔH°; recently reported relationships with a slope of −1 in the fields of enzyme complexes and hydration processes are still more misleading and have arisen only by deliberately selecting the input data.