Promiscuity and the single receptor: NKG2D
- 3 August 2007
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 7 (9), 737-744
- https://doi.org/10.1038/nri2144
Abstract
NKG2D (natural-killer group 2, member D) is a powerful activating receptor expressed by natural killer (NK) cells and T cells that regulates immune responses during infection, cancer and autoimmunity. NKG2D ligands comprise a diverse array of MHC-class-I-related proteins that are upregulated by cellular stress. Why is it beneficial for the host to have so many ligands for the same receptor? In this Opinion article, we propose that although competition with viruses is the most likely evolutionary drive for this diversity, there might be other explanations.Keywords
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