Tuberculosis Associated with HLA—B8, Bf S in a Newfoundland Community Study
- 1 May 1978
- journal article
- research article
- Published by Wiley in Tissue Antigens
- Vol. 11 (5), 403-408
- https://doi.org/10.1111/j.1399-0039.1978.tb01275.x
Abstract
In 3 adjacent Newfoundland communities comprising some 1500 people, 589 people have been HLA typed. Forty-six of the typed people gave a history of previous clinical tuberculosis which required treatment. Fifty-six percent of the TB patients carried HLA B8 compared with 20% of the remainder of the population. This is a highly significant difference (P < 0.01). In each community the frequency of B8 as an epidemiological marker correlated with the incidence of tuberculosis. B8 is associated with TB in this study with a relative risk of 5.2 which compares with combined relative risks in the literature for celiac disease and Addison''s disease of 9.5 and 6.4, respectively, and which is greater than the risks for all the other B8-related diseases. The factor B allele, Bf S, was found on all the B8 haplotypes, but the overall Bf gene frequencies in tuberculosis patients did not deviate from expected values.This publication has 10 references indexed in Scilit:
- HLA Haplotypes in a Genetic Isolate in Newfoundland. A Population Showing 8% Homozygosity and a Familial Aggregate of Lymphoma and Immunodeficiency CasesTissue Antigens, 2008
- Bf Types of HLA Haplotyped Individuals in an Isolated Newfoundland PopulationTissue Antigens, 2008
- Very close linkage between HLA-B and Bf inferred from allelic associationNature, 1977
- Hla in familial hodgkin's disease. Results and a new hypothesisInternational Journal of Cancer, 1977
- The Association of HLA with Autoimmune Thyroid Disease in Newfoundland. The Influence of HLA Homozygosity in Graves’ DiseaseTissue Antigens, 1976
- The HL‐A Type of Rg(a–) IndividualsVox Sanguinis, 1976
- COMMON VARIABLE IMMUNODEFICIENCY, HODGKIN'S DISEASE, AND OTHER MALIGNANCIES IN A NEWFOUNDLAND FAMILYThe Lancet, 1975
- Associations between HL-A histocompatibility antigens and non-malignant diseasesPublished by Springer Nature ,1974
- ON ESTIMATING THE RELATION BETWEEN BLOOD GROUP AND DISEASEAnnals of Human Genetics, 1955