Synthesis of nucleosides and related compounds. Part 21. Synthesis of 9-(t-2,c-3-dihydroxymethyl-r-1-cyclopropyl)-9H-adenine (a lower methylene homolog of carbocyclic oxetanocin) and related compounds.
- 1 January 1990
- journal article
- letter
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 38 (11), 3184-3186
- https://doi.org/10.1248/cpb.38.3184
Abstract
To clarify the relationship of side chain conformation and flexibility to biological activity, a series of carbocyclic analogs of oxetanocin having a one-methylene unit shorter in the cyclobutane ring, 9-(t-2,c-3-dihydroxymethyl-r-1-cyclopropyl)-9H-adenine (11) and the related compounds (15, 18, and 19) were synthesized.This publication has 1 reference indexed in Scilit:
- Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanineProceedings of the National Academy of Sciences, 1977