Isolation and characterization of antibiotic X-14547A, a novel monocarboxylic acid ionophore produced by Streptomyces antibioticus NRRL 8167.
- 1 January 1979
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 32 (2), 100-107
- https://doi.org/10.7164/antibiotics.32.100
Abstract
A novel carboxylic acid ionophore, antibiotic X-14547A, closely related to the polyether antibiotics, was isolated along with 4 other metabolites from fermented cultures of a new strain of S. antibioticus. The structure, determined by X-ray analysis of the R (+)-1-amino-1-(4-bromophenyl)-ethane salt contained pyrrole carbonyl and trans-butadienyl chromophores and the unusual tetrahydroindane bicyclic ring system. A 2nd novel metabolite was identified as 3-ethyl-1,3-methoxy-2H-indol-2-one.This publication has 2 references indexed in Scilit:
- X-14547A, a new ionophorous antibiotic produced by Streptomyces antibioticus NRRL 8167. Discovery, fermentation, biological properties and taxonomy of the producing culture.The Journal of Antibiotics, 1979
- Optical resolution of asymmetric amines by preferential crystallization as lasalocid saltsJournal of the American Chemical Society, 1977