A New Sulfonamide Resistance Gene ( sul3 ) in Escherichia coli Is Widespread in the Pig Population of Switzerland
- 1 March 2003
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 47 (3), 1169-1172
- https://doi.org/10.1128/aac.47.3.1169-1172.2003
Abstract
A new gene, sul3, which specifies a 263-amino-acid protein similar to a dihydropteroate synthase encoded by the 54-kb conjugative plasmid pVP440 from Escherichia coli was characterized. Expression of the cloned sul3 gene conferred resistance to sulfamethoxazole on E. coli. Two copies of the insertion element IS15Δ/26 flanked the region containing sul3. The sul3 gene was detected in one-third of the sulfonamide-resistant pathogenic E. coli isolates from pigs in Switzerland.Keywords
This publication has 24 references indexed in Scilit:
- Efflux of chloramphenicol by the CmlA1 proteinFEMS Microbiology Letters, 2002
- Family of Class 1 Integrons Related to In4 from Tn 1696Antimicrobial Agents and Chemotherapy, 2001
- Resistance to Trimethoprim-SulfamethoxazoleClinical Infectious Diseases, 2001
- Characterization of In53, a Class 1 Plasmid- and Composite Transposon-Located Integron ofEscherichia coliWhich Carries an Unusual Array of Gene CassettesJournal of Bacteriology, 2001
- Sulfonamide resistance: mechanisms and trendsDrug Resistance Updates, 2000
- A new dhfrVIII trimethoprim-resistance gene, flanked by IS26, whose product is remote from other dihydrofolate reductases in parsimony analysisGene, 1995
- IS406 and IS407, two gene-activating insertion sequences from Pseudomonas cepaciaGene, 1991
- Transposition of an antibiotic resistance element in mycobacteriaNature, 1990
- Complete nucleotide sequence and gene organization of the broad-host-range plasmid RSF1010Gene, 1989
- Nucleotide sequence of the transposable element IS15Gene, 1984