BURKITTS-LYMPHOMA IN AIDS - CYTOGENETIC STUDY

Abstract

Cytogenetic studies were done in 2 cases of Burkitt''s lymphoma in homosexual individuals with possible acquired immune deficiency syndrome (AIDS). Chromosomal abnormalities are consistent with those previously described in the nonendemic form of Burkitt''s lymphoma, with 1 of the 2 patients having the variant translocation, t(8;22). The production of the .kappa. light chain Ig by the tumor cells from the patient having t(8;22) and the occurrence of the different sites of translocation of the duplication of 1q in the 2nd patient are unusual findings. Whether there is an increase in the incidence of the variant translocation t(8;22) is yet to be determined.