Augmentation of thromboxane productionin vitro by polymorphonuclears and macrophages exposed to IL1/LP
- 1 January 1986
- journal article
- general inflammation-studies
- Published by Springer Nature in Inflammation Research
- Vol. 17 (3-4), 390-391
- https://doi.org/10.1007/bf01982659
Abstract
Human peripheral blood polymorphonuclear leukocytes (PMNs) and murine peritoneal macrophages (Mø) were stimulated to generate thromboxane upon treatment with highly purified human interleukin 1/leukocytic pyrogen (IL1/LP) at various concentrations. Thromboxane B2 was measured by radioimmunoassay in the cell-free supernatants of cell suspensions after 1 hour incubation at 37°C. Thromboxane B2 amounts increased in a way which depended on the dose of IL1 added to the cell cultures.Keywords
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