Regional Brain Function in Schizophrenia
- 1 February 1987
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 44 (2), 119-125
- https://doi.org/10.1001/archpsyc.1987.01800140021003
Abstract
• Local cerebral glucose metabolism was determined with 18-F-fluorodeoxyglucose using positron emission tomography in a sample of 12 unmedicated schizophrenics and 12 matched normal controls. The data were analyzed for absolute metabolic rates and region/whole-brain ratios using the cortical-subcortical, antero-posterior, and laterality dimensions. Lobar areas within cortical regions were also compared. Across groups, subcortical metabolism was higher than cortical metabolism. Patients had lower metabolism, cortically and subcortically, and a steeper subcortical to cortical gradient. Patients with higher scores on the Brief Psychiatric Rating Scale had higher absolute metabolism and higher left relative to right hemispheric metabolism than did patients with lesser severity. The results did not show "hypofrontality" in schizophrenia. These findings provide some support for cerebral dysfunction in schizophrenia and indicate the need for further examination of the cortical-subcortical dimension.This publication has 29 references indexed in Scilit:
- Anteroposterior Gradients in Cerebral Glucose Use in Schizophrenia and Affective DisordersArchives of General Psychiatry, 1984
- Regional Cerebral Blood Flow in SchizophrenicsArchives of General Psychiatry, 1983
- Regional Cerebral Blood Flow in SchizophreniaArchives of General Psychiatry, 1982
- Cerebral Glucography With Positron TomographyArchives of General Psychiatry, 1982
- Regional cerebral blood flow in schizophrenia: a preliminary reportAmerican Journal of Psychiatry, 1981
- Blood Flow and Oxidative Metabolism of the Brain in Patients with SchizophreniaPsychopathology, 1975
- ABNORMALITIES OF CEREBRAL BLOOD FLOW DISTRIBUTION IN PATIENTS WITH CHRONIC SCHIZOPHRENIAActa Psychiatrica Scandinavica, 1974
- Cerebral blood flow and metabolism in therapeutic insulin comaMetabolism, 1964
- Cerebral Oxygen Uptake in Chronic Schizophrenic ReactionArchives of Neurology & Psychiatry, 1955
- CEREBRAL BLOOD FLOW AND METABOLISM IN SCHIZOPHRENIAAmerican Journal of Psychiatry, 1948