Nonsense suppression context effects in Escherichia coli bacteriophage T4
- 1 May 1987
- journal article
- research article
- Published by Springer Nature in Molecular Genetics and Genomics
- Vol. 207 (2-3), 517-518
- https://doi.org/10.1007/bf00331625
Abstract
Nonsense suppression by supE44 has been examined in a collection of 14 T4 gene 22 and gene 23 UAG mutants, for which the precise gene location is known. In concordance with previous studies, UAG followed by a pyrimidine was inefficiently suppressed. However, among positions with similar 3′ nucleotides, there was considerable variation in suppression efficiency. The competition between supE44 and Release Factor 1 (RF1) was also investigated following the introduction of a multicopy RF1 plasmid. An inverse relationship between the efficiency of suppression and RF1 competition was observed.This publication has 14 references indexed in Scilit:
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