Effect of pregnenolone-16α-carbonitrile (PCN) on drug response in man
- 1 February 1975
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 27 (2), 113-118
- https://doi.org/10.1111/j.2042-7158.1975.tb09418.x
Abstract
Pregnenolone-16α-carbonitrile (PCN), which alters drug responses and induces hepatic microsomal drug-metabolizing enzymes in experimental animals, is well-tolerated in man. There were no marked changes in the concentrations of blood sugar and urea; bromsulphophthalein (BSP) clearance; serum alkaline phosphatase activity; hematocrit, erythrocyte and leukocyte counts; as well as in ecg patterns. When the steroid was given by mouth for 4 days to patients treated with electroshock for psychiatric disorders, it decreased suxamethonium-induced skeletal muscle fasciculation and shortened thiopentone as well as propanidid anaesthesia. Breathing was resumed more rapidly than in control subjects. The protective effect of PCN is probably mediated through induction or activation of hepatic drug-metabolizing enzymes, or both.Keywords
This publication has 14 references indexed in Scilit:
- Comparative studies on the effect of adrenocorticotrophic hormone (ACTH) and pregnenolone-16α-carbonitrile (PCN) upon drug response and distribution in ratsBiochemical Pharmacology, 1974
- Effect of Various Steroids and ACTH on Plasma Levels of Zoxazolamine and DicumarolJournal of Pharmaceutical Sciences, 1973
- Effects of a Potent Catatoxic Steroid, 16α‐Cyanopregnenolone, on Microsomal Metabolism of Steroid Hormones, Sterols and Bile Acids in RatsEuropean Journal of Biochemistry, 1973
- Metabolic Interactions Among Environmental Chemicals and DrugsScience, 1972
- The influence of pregnenolone-16α-carbonitrile on hepatic mixed-function oxygenasesSteroids, 1971
- Effect of catatoxic steroids upon established morbid changesCellular and Molecular Life Sciences, 1971
- Suppression of 7, 12-dimethylbenz[α]anthracene-produced adrenal necrosis by steroids capable of inducing aryl hydrocarbon hydroxylaseLife Sciences, 1971
- Protection by steroids against acute HgCl2 poisoningInternational Urology and Nephrology, 1970
- The addition of hydrocyanic acid to Δ16-pregnen-20-onesTetrahedron, 1958
- A TABLE FOR THE CALCULATION OF WORKING PROBITS AND WEIGHTS IN PROBIT ANALYSISBiometrika, 1948