Occurrence of spontaneous hemorrhagic necrosis of the central nervous system in fetal hamsters
- 1 February 1975
- journal article
- Published by Wiley in Teratology
- Vol. 11 (1), 21-30
- https://doi.org/10.1002/tera.1420110103
Abstract
Lesions of hamster fetal neuraxial tissues, characterized by multifocal and coalescent zones of hemorrhage, edema, and necrosis in the cerebral mantle, brainstem, and spinal cord, were observed in experiments designed to test the teratogenicity of potato preparations. Retrospective and prospective data indicated, however, that the potato preparations were not responsible but that the disease occurred spontaneously in the colony and was associated with direct breeding contact of virgin females with certain males. Observations suggest that an infectious agent may be responsible, but no agent was recovered. Immunofluorescence assay of inoculated cultures indicated that reovirus was not present in affected fetal tissues.Keywords
This publication has 2 references indexed in Scilit:
- Failure of Blighted Russet Burbank Potatoes to Produce Congenital Deformities in RatsExperimental Biology and Medicine, 1974
- Enhancement of Reovirus Infectivity by Extracellular Removal or Alteration of the Virus Capsid by Proteolytic EnzymesJournal of General Virology, 1970