Acute Effects of Guanethidine on Myocardial Contractility and Catecholamine Levels.

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Abstract
Dog studies indicate that guanethidine causes acute myocardial stimulation. The agent significantly decreases the concentration of norepinephrine in cardiac and aortic tissues of dogs; however, plasma levels of catecholamines are not altered during the acute stimulation. Isolated rabbit hearts, display myocardial stimulation and release norepinephrine when injected with this agent.