DEVELOPMENTAL CHANGES AND HETEROGENEITY OF LACTIC AND MALIC DEHYDROGENASES OF HUMAN SKELETAL MUSCLES AND OTHER ORGANS

Abstract

The LDH isoenzyme patterns of normal human skeletal muscles and visceral organs have been found to vary greatly, ranging from predominant [image] type to H type. The human fetal type of LDH has been shown to be of the electrophoretically rapid migrating H type. During maturation and development after birth there occurs a shift toward the [image] type in most muscles like quadriceps, psoas, deltoid, and pectoralis, and in organs like the liver. MDH does not show any very characteristic pattern in different muscles and organs. In future studies on LDH isoenzymes in skeletal muscle it will be necessary to recognize both the specificity and the heterogeneity of that tissue.