A Conformationally Constrained Vasopressin Analog with Antidiuretic Antagonistic Activity
- 26 October 1984
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 226 (4673), 443-445
- https://doi.org/10.1126/science.6541806
Abstract
Application of information derived from a 3-dimensional model of vasopressin bound to its antidiuretic receptor resulted in the design and synthesis of a bicyclic vasopressin analog, [5,8-cyclo(1-.beta.-mercaptopropionic acid, 2-phenylalanine, 5-aspartic acid, 8-lysine)]vasopressin. The analog acts as an antagonist of the antidiuretic activity of vasopressin.Keywords
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