THE PLASMA DISTRIBUTION OF BENZOPORPHYRIN DERIVATIVE and THE EFFECTS OF PLASMA LIPOPROTEINS ON ITS BIODISTRIBUTION
- 1 September 1990
- journal article
- research article
- Published by Wiley in Photochemistry and Photobiology
- Vol. 52 (3), 501-507
- https://doi.org/10.1111/j.1751-1097.1990.tb01792.x
Abstract
The plasma distribution and biodistribution of benzoporphyrin derivative were examined. Two analogs of benzoporphyrin derivative were mixed with human plasma in vitro and recovered in the lipoprotein fractions upon separation by chromatography or ultracentrifugation. The majority of both analogs was recovered with high density lipoprotein. The effect of prebinding benzoporphyrin derivative to lipoproteins on the biodistribution of the drug in vivo was studied in tumor bearing DBA/2J mice. At 3, 8 and 24 h post-injection, tumor and tissue samples were excised and analyzed for benzoporphyrin derivative content. Precomplexing benzoporphyrin derivative with low density lipoprotein or high density lipoprotein led to significantly (P < 0.05) greater tumor accumulation than in aqueous solution.This publication has 16 references indexed in Scilit:
- Biodistribution of tritiated benzoporphyrin derivative (3H-BPD-MA), a new potent photosensitizer, in normal and tumor-bearing miceJournal of Photochemistry and Photobiology B: Biology, 1990
- In vitro PHOTOSENSITIZATION WITH A BENZOPORPHYRIN DERIVATIVEPhotochemistry and Photobiology, 1989
- AN ULTRASTRUCTURAL COMPARATIVE EVALUATION OF TUMORS PHOTOSENSITIZED BY PORPHYRINS ADMINISTERED IN AQUEOUS SOLUTION, BOUND TO LIPOSOMES OR TO LIPOPROTEINSPhotochemistry and Photobiology, 1988
- Lecithin:cholesterol acyltransferase in familial HDL deficiency (Tangier disease)Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1988
- Porphyrin-lipoprotein association as a factor in porphyrin localizationCancer Letters, 1986
- Role of high-, low- and very low-density lipoproteins in the transport and tumor-delivery of hematoporphyrin in vivoCancer Letters, 1986
- [7] Density gradient ultracentrifugation of serum lipoproteins in a swinging bucket rotorMethods in Enzymology, 1986
- INTERACTION OF HUMAN SERUM LOW DENSITY LIPOPROTEINS WITH PORPHYRINS: A SPECTROSCOPIC AND PHOTOCHEMICAL STUDYPhotochemistry and Photobiology, 1984
- Evidence for a major role of plasma lipoproteins as hematoporphyrin carriers in vivoCancer Letters, 1984
- THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUMJournal of Clinical Investigation, 1955