Combined Systemic and Topical Therapy with Metronidazole for Vaginal Trichomoniasis

Abstract

Failure of local treatment of infestation with Trichomonas vaginalis in the female is largely attributable to inability of such therapy to eradicate extravaginal foci of infection. Symptomatic relief may persist for weeks or months, but when conditions are again favorable for their survival, trichomonads reinvade the vagina. A second factor often responsible for reinfection is that male consorts who harbor the infection are not effectively treated.Since vaginitis recurs in virgins and women who are not indulging in coitus, extravaginal foci of infection are probably the most important single cause of treatment failure. This implies the necessity for a systemically . . .