RENAL CIRCULATORY DYNAMICS AND URINARY PROTEIN EXCRETION DURING INFUSIONS OF l-NOREPINEPHRINE AND l-EPINEPHRINE IN PATIENTS WITH RENAL DISEASE 12

Abstract

Administration of 1-norepinephrine and 1-epinephrine to patients with chronic renal disease and protenuria abruptly increased the urinary excretion and renal clearance of plasma proteins. These changes occurred independently of alterations in systemic blood pressure, glomerular filtration rate and probably independently of changes in intraglomerular pressure. The increase in protein output was best correlated with a reduction in renal blood flow, suggesting that the rate of blood flow conditioned in some manner the transglomerular capillary transport of protein molecules.