Isolation and Amino Acid Sequence of α2-Corticotropin-Releasing Factor (α2-CRF) from Hog Pituitary Glands
- 30 June 1962
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 71 (1), 164-173
- https://doi.org/10.1210/endo-71-1-164
Abstract
An α-MSH-like peptide has been isolated from hog pituitary glands. This peptide, designated α2-CRF, has CRF activity, identical melanophoretic activity with α-MSH, but a lower inherent adrenocorticotropic activity than α-MSH. Natural or synthetic α-MSH is inactive CRF-wise at equivalent dry weight doses. α2-CRF has an identical amino acid sequence with that of α-MSH, but a discrete structural change at the N-terminus, as compared with α-MSH, may be responsible for the appearance of corticotropin-releasing activity.Keywords
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