Ethacrynic Acid in Acute Pulmonary Edema

Abstract

DIURETICS are frequently used as part of the therapeutic regimen in the management of patients in acute pulmonary edema. The decreased cardiac output and reduced glomerular filtration rate of patients in acute pulmonary edema often result in a disappointing diuretic response, even with the most potent diuretics currently available. The delay of four to six hours in the onset of action of the mercurial diuretics reduces their effectiveness in altering the immediate course of acute pulmonary edema. There is a need, then, for a potent diuretic agent with a rapid onset of action that would promote an effective diuresis within . . .