DNA‐binding by Functionalized Gold Nanoparticles: Mechanism and Structural Requirements
Open Access
- 18 April 2006
- journal article
- Published by Wiley in Chemical Biology & Drug Design
- Vol. 67 (4), 297-304
- https://doi.org/10.1111/j.1747-0285.2006.00372.x
Abstract
A family of nanoparticles featuring surfaces of varying hydrophobicity was synthesized. The efficiency of DNA‐binding was determined, demonstrating in a fivefold modulation in binding a 37‐mer DNA strand. Nanoparticle‐binding causes a reversible conformational change in the DNA structure, as demonstrated by circular dichroism and fluorescence experiments. Furthermore, the affinity of the nanoparticle for the DNA can be regulated by external agents, though stability of the complex is observed at relatively high ionic strengths.Keywords
This publication has 50 references indexed in Scilit:
- Allosteric Inhibition of Zinc-Finger Binding in the Major Groove of DNA by Minor-Groove Binding LigandsBiochemistry, 2004
- The Design of Functional DNA-Binding Proteins Based on Zinc Finger DomainsChemical Reviews, 2003
- From transcription factors to designed sequence-specific DNA-binding peptidesChemical Society Reviews, 2003
- Allosteric Inhibition of Protein−DNA Complexes by Polyamide−Intercalator ConjugatesJournal of the American Chemical Society, 2003
- Combinatorial Determination of Sequence Specificity for Nanomolar DNA-Binding Hairpin PolyamidesBiochemistry, 2003
- Sequence-Selective DNA Cleavage by a Chimeric MetallopeptideJournal of the American Chemical Society, 2003
- Inhibition of Transcription at a Coding Sequence by Alkylating PolyamideJournal of the American Chemical Society, 2003
- Hydroxybenzamide/Pyrrole Pair Distinguishes T·A from A·T Base Pairs in the Minor Groove of DNAJournal of the American Chemical Society, 2000
- Peptide Ribonucleic Acids (PRNA). 2. A Novel Strategy for Active Control of DNA Recognition through Borate Ester FormationJournal of the American Chemical Society, 2000
- Novel Recognition of Thymine Base in Double-Stranded DNA by Zinc(II)−Macrocyclic Tetraamine Complexes Appended with Aromatic GroupsJournal of the American Chemical Society, 1999