Surfactant-Assisted Synthesis of Water-Soluble and Biocompatible Semiconductor Quantum Dot Micelles
- 1 March 2005
- journal article
- letter
- Published by American Chemical Society (ACS) in Nano Letters
- Vol. 5 (4), 645-648
- https://doi.org/10.1021/nl050017l
Abstract
We report a simple, rapid approach to synthesize water-soluble and biocompatible fluorescent quantum dot (QD) micelles by encapsulation of monodisperse, hydrophobic QDs within surfactant/lipid micelles. Analyses of UV−vis and photo luminescence spectra, along with transmission electron microscopy, indicate that the water-soluble semiconductor QD micelles are monodisperse and retain the optical properties of the original hydrophobic QDs. The QD micelles were shown to be biocompatible and exhibited little or no aggregation when taken up by cultured rat hippocampal neurons.Keywords
This publication has 16 references indexed in Scilit:
- Luminescence Temperature Antiquenching of Water-Soluble CdTe Quantum Dots: Role of the SolventJournal of the American Chemical Society, 2004
- Hydrophobic Nanocrystals Coated with an Amphiphilic Polymer Shell: A General Route to Water Soluble NanocrystalsNano Letters, 2004
- Self-assembled nanoscale biosensors based on quantum dot FRET donorsNature Materials, 2003
- Growth and morphology of cadmium chalcogenides: the synthesis of nanorods, tetrapods, and spheres from CdO and Cd(O2CCH3)2Journal of Materials Chemistry, 2003
- In Vivo Imaging of Quantum Dots Encapsulated in Phospholipid MicellesScience, 2002
- Recognition Molecule Directed Interfacing Between Semiconductor Quantum Dots and Nerve CellsAdvanced Materials, 2001
- Photochemical Instability of CdSe Nanocrystals Coated by Hydrophilic ThiolsJournal of the American Chemical Society, 2001
- Synthesis and Properties of Biocompatible Water-Soluble Silica-Coated CdSe/ZnS Semiconductor Quantum DotsThe Journal of Physical Chemistry B, 2001
- Self-Assembly of CdSe−ZnS Quantum Dot Bioconjugates Using an Engineered Recombinant ProteinJournal of the American Chemical Society, 2000
- Semiconductor Nanocrystals as Fluorescent Biological LabelsScience, 1998