Dynamic studies of prostaglandin F-2 in the utero-ovarian circulation of the sheep
- 1 July 1976
- journal article
- research article
- Published by Bioscientifica in Reproduction
- Vol. 47 (2), 209-214
- https://doi.org/10.1530/jrf.0.0470209
Abstract
The concentration of prostaglandin (PG) F2.alpha. in ovarian arterial blood was compared to that in aortic and carotid blood at different stages of the ovine estrous cycle, and its concentration measured in the ovarian artery following the infusion of radioactive PGF2.alpha. to the uterine vein. In all cases the concentration of PGF2.alpha. increased during passage through the ovarian artery, and the increase was proportional to the log of the concentration in the uterine vein. No such change was observed in the concentration of progesterone in the ovarian artery or of PGF in the uterine artery. PGF2.alpha. can be and is normally transferred from the uterine vein to the ovarian artery. These results are compatible with the hypothesis that PGF2.alpha. of uterine origin is the normal luteolytic agent in the sheep.This publication has 2 references indexed in Scilit:
- ENDOCRINE CHANGES ASSOCIATED WITH LUTEAL REGRESSION IN THE EWE; THE SECRETION OF OVARIAN OESTRADIOL, PROGESTERONE AND ANDROSTENEDIONE AND UTERINE PROSTAGLANDIN F2α THROUGHOUT THE OESTROUS CYCLEJournal of Endocrinology, 1976
- LOCAL UTERINE MECHANISMS AFFECTING LUTEAL FUNCTION IN THE SHEEPReproduction, 1966